Vitacura
Is located pretty far east towards the andes. it is composed of bars and some places where you can dance. the places are nice and although they certainly lack cohesiveness as nightlife since bars only recently started opening there it can be fun to go. it is more expensive that other areas of santiago and frequented by people that live in the eastern wealthier side of the city. although you can get there by bus, it will be hard to leave on anything but a taxi since buses don't run late.
Suecia
Is roughly located at providencia and suecia, in between metro tobalaba and los leones line 1. it is a boulevard of bars and discos about 3 blocks long. it used to cater to a foreign and upscale audience, but it seems now that the most entertaining bars moved to manuel montt.
The Santiago Pub Crawl
. Your night is planned out for you so you don't have worry about where to go, you meet people from all over the world, cover a lot of ground and it's great value for your money.
Plaza San Enrique
Is a park located in lo barnechea at the far north-east of the city which is surrounded by nightclubs. the most popular one is sala murano it can get very crowded!. people who attend are mostly 18-25 and it is one of the safest places to party. most people there are from upper-middle to high class, so it is more expensive than other neighbourhoods. typically, females get in for free, while males pay around 3k-5k clp. you can get there by micro, but though buses do pass later on, you might have to wait up to an hour for it.
Bar Catedral
Nice bar downtown between between lounge bar and more folklorica. Good rock bands often come to play.
Batuta
A good spot to see mainstream Chilean rock and metal bands, although it is expensive by Chilean standards.
Bar Liguria
This bar looks like a 1950's American diner and plays music ranging from classic 1950s rock to what you'd hear in a mid-2000's London pub. For all that, it's clearly no tourist trap and the clientele are mainly local. At the weekend the bars on Pio Nono are probably a better bet, but for a mid-week drink this is well worth a visit. It is also a great restaurant during the day! It serves many local dishes and drinks, including great wines.
Isidora Goyenechea
Is a very nice and safe neighbourhood with plenty of restaurants, albeit expensive ones. take the metro to el golf.
Plaza Ãuñoa
Is a district east of the central area and is another popular spot nightlife spot.
Boomerang
High scale pub and cocktail bar.
Pio Nono in Bella Vista has an intense feeling, bars line the street on either side. The area has a very youthful quality but older visitors shouldn't be intimidated. One of the most lively areas of the city at the weekend.
Barrio Manuel Montt
Has a small and unique atmosphere with mid-range prices. it can be reached at metro manuel montt line 1.
El Candil
A quiet bar/restaurant in Providencia. The traffic outside is noticeable but not excessive and drinking outside here has a genuinely pleasant urban flavour. If you fancy making a night of it, Bar Liguria is practically next door.
Nightlife choices vary widely across the city and their location usually reflects their price and style.
Barrio Bellavista
And barrio brasil are popular spots close to the city center. bellavista can be reached by metro to baquedano, or by bus to plaza italia. cross the bridge will bring you to pio nono, which probably has highest density of bars in chile. bellavista has a wide range of choices from popular places to upscale, such as a jazz bar. in addition, there are discos with all kinds of music, from contemporary eletro-pop to salsa and merengue. this is probably the only barrio where you can find a disco that has a predominately gay audience. it is a fun atmosphere and features drag-queen shows during saturday nights. moreover, bellavista is the area that lasts the longest during friday and saturday nights, with most places closing at 4-5am, and a few places so called "after hours" run till 6-7am.
La Casa Club
Five level club with each floor catering to different musical tastes, laser show, bar and special events, highly recommended.
La Leyenda
This Peruvian restaurant/bar plays music from all over Latin America at weekends until 5AM to a diverse crowd of locals with roots all over South America. Unpretentious and entertaining.